The parallel growth of motoneuron axons with the dorsal aorta depends on Vegfc/Vegfr3 signaling in zebrafish
Identifieur interne : 003063 ( Main/Exploration ); précédent : 003062; suivant : 003064The parallel growth of motoneuron axons with the dorsal aorta depends on Vegfc/Vegfr3 signaling in zebrafish
Auteurs : Hyouk-Bum Kwon [Japon] ; Shigetomo Fukuhara [Japon] ; Kazuhide Asakawa [Japon] ; Koji Ando [Japon] ; Takeru Kashiwada [Japon] ; Koichi Kawakami [Japon] ; Masahiko Hibi [Japon] ; Young-Guen Kwon [Corée du Sud] ; Kyu-Won Kim [Corée du Sud] ; Kari Alitalo [Finlande] ; Naoki Mochizuki [Japon]Source :
- Development (Cambridge, England) [ 0950-1991 ] ; 2013.
Abstract
Blood vessels and neurons grow often side by side. However, the molecular and cellular mechanisms underlying their parallel development remain unclear. Here, we report that a subpopulation of secondary motoneurons extends axons ventrally outside of the neural tubes and rostrocaudally as a fascicle beneath the dorsal aorta (DA) in zebrafish. We tried to clarify the mechanism by which these motoneuron axons grow beneath the DA and found that Vegfc in the DA and Vegfr3 in the motoneurons were essential for the axon growth. Forced expression of either Vegfc in arteries or Vegfr3 in motoneurons resulted in enhanced axon growth of motoneurons over the DA. Both
Url:
DOI: 10.1242/dev.091702
PubMed: 24046321
PubMed Central: 3913045
Affiliations:
- Corée du Sud, Finlande, Japon
- Région capitale de Séoul, Uusimaa
- Helsinki, Séoul
- Université d'Helsinki, Université nationale de Séoul
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Vegfc/Vegfr3 signaling in zebrafish</title><author><name sortKey="Kwon, Hyouk Bum" sort="Kwon, Hyouk Bum" uniqKey="Kwon H" first="Hyouk-Bum" last="Kwon">Hyouk-Bum Kwon</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Cell Biology, National Cerebral and Cardiovascular Center Research Institute, 5-7-1 Fujishirodai, Suita, Osaka 565-8565, Japan.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Japon</country><wicri:regionArea> Department of Cell Biology, National Cerebral and Cardiovascular Center Research Institute, 5-7-1 Fujishirodai, Suita, Osaka 565-8565</wicri:regionArea><wicri:noRegion>Osaka 565-8565</wicri:noRegion></affiliation></author><author><name sortKey="Fukuhara, Shigetomo" sort="Fukuhara, Shigetomo" uniqKey="Fukuhara S" first="Shigetomo" last="Fukuhara">Shigetomo Fukuhara</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Cell Biology, National Cerebral and Cardiovascular Center Research Institute, 5-7-1 Fujishirodai, Suita, Osaka 565-8565, Japan.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Japon</country><wicri:regionArea> Department of Cell Biology, National Cerebral and Cardiovascular Center Research Institute, 5-7-1 Fujishirodai, Suita, Osaka 565-8565</wicri:regionArea><wicri:noRegion>Osaka 565-8565</wicri:noRegion></affiliation></author><author><name sortKey="Asakawa, Kazuhide" sort="Asakawa, Kazuhide" uniqKey="Asakawa K" first="Kazuhide" last="Asakawa">Kazuhide Asakawa</name><affiliation wicri:level="1"><nlm:aff id="A2"> Division of Molecular and Developmental Biology, National Institute of Genetics, Mishima, Shizuoka 411-8540, Japan.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Japon</country><wicri:regionArea> Division of Molecular and Developmental Biology, National Institute of Genetics, Mishima, Shizuoka 411-8540</wicri:regionArea><wicri:noRegion>Shizuoka 411-8540</wicri:noRegion></affiliation></author><author><name sortKey="Ando, Koji" sort="Ando, Koji" uniqKey="Ando K" first="Koji" last="Ando">Koji Ando</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Cell Biology, National Cerebral and Cardiovascular Center Research Institute, 5-7-1 Fujishirodai, Suita, Osaka 565-8565, Japan.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Japon</country><wicri:regionArea> Department of Cell Biology, National Cerebral and Cardiovascular Center Research Institute, 5-7-1 Fujishirodai, Suita, Osaka 565-8565</wicri:regionArea><wicri:noRegion>Osaka 565-8565</wicri:noRegion></affiliation></author><author><name sortKey="Kashiwada, Takeru" sort="Kashiwada, Takeru" uniqKey="Kashiwada T" first="Takeru" last="Kashiwada">Takeru Kashiwada</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Cell Biology, National Cerebral and Cardiovascular Center Research Institute, 5-7-1 Fujishirodai, Suita, Osaka 565-8565, Japan.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Japon</country><wicri:regionArea> Department of Cell Biology, National Cerebral and Cardiovascular Center Research Institute, 5-7-1 Fujishirodai, Suita, Osaka 565-8565</wicri:regionArea><wicri:noRegion>Osaka 565-8565</wicri:noRegion></affiliation></author><author><name sortKey="Kawakami, Koichi" sort="Kawakami, Koichi" uniqKey="Kawakami K" first="Koichi" last="Kawakami">Koichi Kawakami</name><affiliation wicri:level="1"><nlm:aff id="A2"> Division of Molecular and Developmental Biology, National Institute of Genetics, Mishima, Shizuoka 411-8540, Japan.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Japon</country><wicri:regionArea> Division of Molecular and Developmental Biology, National Institute of Genetics, Mishima, Shizuoka 411-8540</wicri:regionArea><wicri:noRegion>Shizuoka 411-8540</wicri:noRegion></affiliation></author><author><name sortKey="Hibi, Masahiko" sort="Hibi, Masahiko" uniqKey="Hibi M" first="Masahiko" last="Hibi">Masahiko Hibi</name><affiliation wicri:level="1"><nlm:aff id="A3"> Laboratory of Organogenesis and Organ Functions, Bioscience and Biotechnology Center, Nagoya University, Furo, Chikusaku, Nagoya 464-8601, Japan.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Japon</country><wicri:regionArea> Laboratory of Organogenesis and Organ Functions, Bioscience and Biotechnology Center, Nagoya University, Furo, Chikusaku, Nagoya 464-8601</wicri:regionArea><wicri:noRegion>Nagoya 464-8601</wicri:noRegion></affiliation></author><author><name sortKey="Kwon, Young Guen" sort="Kwon, Young Guen" uniqKey="Kwon Y" first="Young-Guen" last="Kwon">Young-Guen Kwon</name><affiliation wicri:level="1"><nlm:aff id="A4"> Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 120-749, Republic of Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea> Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 120-749</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Kyu Won" sort="Kim, Kyu Won" uniqKey="Kim K" first="Kyu-Won" last="Kim">Kyu-Won Kim</name><affiliation wicri:level="4"><nlm:aff id="A5"> NeuroVascular Coordination Research Center, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 151-742, Republic of Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea> NeuroVascular Coordination Research Center, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 151-742</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region><settlement type="city">Séoul</settlement></placeName><orgName type="university">Université nationale de Séoul</orgName></affiliation></author><author><name sortKey="Alitalo, Kari" sort="Alitalo, Kari" uniqKey="Alitalo K" first="Kari" last="Alitalo">Kari Alitalo</name><affiliation wicri:level="4"><nlm:aff id="A6"> Wihuri Research Institute and Translational Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, PO Box 63, Haartmaninkatu 8, 00014 Helsinki, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea> Wihuri Research Institute and Translational Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, PO Box 63, Haartmaninkatu 8, 00014 Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName><orgName type="university">Université d'Helsinki</orgName></affiliation></author><author><name sortKey="Mochizuki, Naoki" sort="Mochizuki, Naoki" uniqKey="Mochizuki N" first="Naoki" last="Mochizuki">Naoki Mochizuki</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Cell Biology, National Cerebral and Cardiovascular Center Research Institute, 5-7-1 Fujishirodai, Suita, Osaka 565-8565, Japan.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Japon</country><wicri:regionArea> Department of Cell Biology, National Cerebral and Cardiovascular Center Research Institute, 5-7-1 Fujishirodai, Suita, Osaka 565-8565</wicri:regionArea><wicri:noRegion>Osaka 565-8565</wicri:noRegion></affiliation></author></analytic><series><title level="j">Development (Cambridge, England)</title><idno type="ISSN">0950-1991</idno><idno type="eISSN">1477-9129</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Blood vessels and neurons grow often side by side. However, the molecular and cellular mechanisms underlying their parallel development remain unclear. Here, we report that a subpopulation of secondary motoneurons extends axons ventrally outside of the neural tubes and rostrocaudally as a fascicle beneath the dorsal aorta (DA) in zebrafish. We tried to clarify the mechanism by which these motoneuron axons grow beneath the DA and found that Vegfc in the DA and Vegfr3 in the motoneurons were essential for the axon growth. Forced expression of either Vegfc in arteries or Vegfr3 in motoneurons resulted in enhanced axon growth of motoneurons over the DA. Both <italic>vegfr3</italic> morphants and <italic>vegfc</italic> morphants lost the alignment of motoneuron axons with DA. In addition, forced expression of two mutant forms of Vegfr3 in motoneurons, potentially trapping endogenous Vegfc, resulted in failure of growth of motoneuron axons beneath the DA. Finally, a <italic>vegfr3</italic> mutant fish lacked the motoneuron axons beneath the DA. Collectively, Vegfc from the preformed DA guides the axon growth of secondary motoneurons.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Adams, R H" uniqKey="Adams R">R. H. Adams</name></author><author><name sortKey="Eichmann, A" uniqKey="Eichmann A">A. Eichmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Asakawa, K" uniqKey="Asakawa K">K. Asakawa</name></author><author><name sortKey="Suster, M L" uniqKey="Suster M">M. L. Suster</name></author><author><name sortKey="Mizusawa, K" uniqKey="Mizusawa K">K. Mizusawa</name></author><author><name sortKey="Nagayoshi, S" uniqKey="Nagayoshi S">S. Nagayoshi</name></author><author><name sortKey="Kotani, T" uniqKey="Kotani T">T. Kotani</name></author><author><name sortKey="Urasaki, A" uniqKey="Urasaki A">A. 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Castranova</name></author><author><name sortKey="Dye, L" uniqKey="Dye L">L. Dye</name></author><author><name sortKey="Hitomi, J" uniqKey="Hitomi J">J. Hitomi</name></author><author><name sortKey="Weinstein, B M" uniqKey="Weinstein B">B. M. Weinstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yusa, K" uniqKey="Yusa K">K. Yusa</name></author><author><name sortKey="Rad, R" uniqKey="Rad R">R. Rad</name></author><author><name sortKey="Takeda, J" uniqKey="Takeda J">J. Takeda</name></author><author><name sortKey="Bradley, A" uniqKey="Bradley A">A. Bradley</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Corée du Sud</li><li>Finlande</li><li>Japon</li></country><region><li>Région capitale de Séoul</li><li>Uusimaa</li></region><settlement><li>Helsinki</li><li>Séoul</li></settlement><orgName><li>Université d'Helsinki</li><li>Université nationale de Séoul</li></orgName></list><tree><country name="Japon"><noRegion><name sortKey="Kwon, Hyouk Bum" sort="Kwon, Hyouk Bum" uniqKey="Kwon H" first="Hyouk-Bum" last="Kwon">Hyouk-Bum Kwon</name></noRegion><name sortKey="Ando, Koji" sort="Ando, Koji" uniqKey="Ando K" first="Koji" last="Ando">Koji Ando</name><name sortKey="Asakawa, Kazuhide" sort="Asakawa, Kazuhide" uniqKey="Asakawa K" first="Kazuhide" last="Asakawa">Kazuhide Asakawa</name><name sortKey="Fukuhara, Shigetomo" sort="Fukuhara, Shigetomo" uniqKey="Fukuhara S" first="Shigetomo" last="Fukuhara">Shigetomo Fukuhara</name><name sortKey="Hibi, Masahiko" sort="Hibi, Masahiko" uniqKey="Hibi M" first="Masahiko" last="Hibi">Masahiko Hibi</name><name sortKey="Kashiwada, Takeru" sort="Kashiwada, Takeru" uniqKey="Kashiwada T" first="Takeru" last="Kashiwada">Takeru Kashiwada</name><name sortKey="Kawakami, Koichi" sort="Kawakami, Koichi" uniqKey="Kawakami K" first="Koichi" last="Kawakami">Koichi Kawakami</name><name sortKey="Mochizuki, Naoki" sort="Mochizuki, Naoki" uniqKey="Mochizuki N" first="Naoki" last="Mochizuki">Naoki Mochizuki</name></country><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Kwon, Young Guen" sort="Kwon, Young Guen" uniqKey="Kwon Y" first="Young-Guen" last="Kwon">Young-Guen Kwon</name></region><name sortKey="Kim, Kyu Won" sort="Kim, Kyu Won" uniqKey="Kim K" first="Kyu-Won" last="Kim">Kyu-Won Kim</name></country><country name="Finlande"><region name="Uusimaa"><name sortKey="Alitalo, Kari" sort="Alitalo, Kari" uniqKey="Alitalo K" first="Kari" last="Alitalo">Kari Alitalo</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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